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The purpose of this study is to test the effects of a 3 year diet intervention of the MIND Diet on cognitive decline and brain neurodegeneration. The study will take place at 2 sites: ÍÑÒÂÖ±²¥ and Harvard School of Public Health. A total of 600 people will be recruited for this study. At ÍÑÒÂÖ±²¥, we expect to recruit 300 participants. The weight loss diets will be assigned randomly.

In order to participate you must meet the following criteria:

• Are between the ages of 65 and 84.
• Have a family history of dementia, but without personal cognitive impairment.
• Are overweight/obese (BMI above 25).
• Have a suboptimal/poor diet.

You will be excluded from the study if any of the following criteria apply to you:

• Have cognitive impairment.
• Use medications to treat Alzheimer’s disease or Parkinson’s disease.
• Have a current diagnosis of psychosis or bipolar disorder.
• Report alcohol or substance abuse within the past 6 months.
• Have been diagnosed with cardiovascular disease within the past 6 months.
• Have HIV or hepatitis C.

This is a partial list of inclusion and exclusion criteria.